To describe the regional differences in the innate immune system of the skin using intra-vital multiphoton microscopy and understand its functional consequences in a cutaneous parasite infection model.

使用活体多光子显微镜描述皮肤先天免疫系统的区域差异，并了解其在皮肤寄生虫感染模型中的功能后果。

• 批准号: nhmrc : 1038704
• 负责人: Dr Philip Tong
• 金额: $ 6.48万
• 依托单位: Centenary Institute of Cancer Medicine and Cell Biology
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Postgraduate Scholarships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regional-differences-innate-infection-model/111203
• 关键词: describe; regional; differences; innate; immune

This study is the first of its kind to map the innate immune system, the body's first line of defence, in the skin - coined the "immune atlas". Researchers have shown regional differences in innate immune cells which could explain how infections develop at different sites of the body. Although they have shown this in a cutaneous leishmaniasis model, a parasite endemic in most parts of the world, it may have implications also for inflammatory skin conditions such as eczema or psoriasis.

这项研究是同类研究中首次绘制人体皮肤内的先天免疫系统（人体的第一道防线）的图谱，被称为“免疫图谱”。研究人员发现了先天免疫细胞的区域差异，这可以解释感染是如何在身体不同部位发生的。尽管他们已经在皮肤利什曼病模型（一种在世界大部分地区流行的寄生虫）中证明了这一点，但它也可能对湿疹或牛皮癣等炎症性皮肤病有影响。