Australia Fellowship - Grant ID:631668

点击翻译按钮获取中文摘要

Through the Australia Fellowship Prof Mattick will lead a team of researchers to explore the scientific and applied dimensions of the thesis that the human genome is not largely comprised of evolutionary debris, but encodes an extraordinarily sophisticated information suite that is largely transacted by RNA. The work will include examination of the expression patterns on noncoding RNAs in different tissues and cells and different disease states, exploration of the location and dynamics of RNAs associated with DNA and various proteins to determine how these RNAs influence gene expression, targeted functional analyses of selected subsets of these RNAs to determine their biological function as proof-of-principle for others, exploration of the roles of RNA editing proteins, and testing of the hypothesis that RNA-directed DNA recoding might underpin memory formation. If correct, the results of the project will transform our understanding of human biology, development, and brain function, and create an enlightened framework for future research into human health and disease.