Better targets and drugs for improving stroke outcome?

改善中风结果的更好靶点和药物？

• 批准号: nhmrc : GNT1104036
• 负责人: Dr Connie Wong
• 金额: $ 108.6万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/better-targets-drugs-stroke-outcome/1346328
• 关键词: Better; targets; drugs; improving; stroke

Infection is highly prevalent and is one of the leading causes of death in stroke. It is now recognised that stroke impairs the immune system, raising the possibility that reversing this impairment can decrease the rate of infection after stroke. Therefore, the focus of this project is to identify the signalling pathways that underlie abnormal immune function after stroke and also assess the potential of a novel pharmacological approach for reducing bacterial infection in stroke patients.

感染非常普遍，是中风死亡的主要原因之一。现在人们认识到，中风会损害免疫系统，这提高了逆转这种损害可以降低中风后感染率的可能性。因此，该项目的重点是确定中风后免疫功能异常的信号通路，并评估减少中风患者细菌感染的新药理学方法的潜力。