Dual-station glove box for the manipulation of sensitive synthetic intermediates

对建筑复杂目标的综合研究往往会导致创新和创造性的纽带断开。因此，我们的研究以天然产物为灵感来开发新的合成方法。这一新方法包括使用有机金属试剂来开发新的键结构技术，用于全合成的构筑基团的对映选择性合成，以及用于快速、非对映选择性合成密集官能化分子的级联过程的开发和评估。我的研究计划的所有目标的核心是使用高活性的有机化合物和金属络合物，无论它们是不对称催化剂、敏感的有机中间体，还是用于级联反应的钯催化剂。大多数这些化合物和络合物既对空气和湿度敏感，又对级联反应敏感必须在惰性气氛中使用严格干燥的溶剂进行处理。我们目前没有能力充分存储和操作我们日常使用的高活性络合物。因此，带溶剂净化系统的手套箱对于本研究计划的每个方面都是必不可少的。

Synthetic investigations into architecturally complex targets often lead to innovative and creative bond disconnections. Our research, therefore, uses natural products as inspiration for the development of new synthetic methodology.  This new methodology encompasses the use of organometallic reagents for the development of new bond construction techniques, the enantioselective synthesis of building blocks for total synthesis, and the development and evaluation of cascade processes for the rapid, diastereoselective synthesis of densely functionalized molecules.         Central to all of the goals of my research program is the use of highly reactive organic compounds and metal complexes, whether they are asymmetric catalysts, sensitive organic intermediates, or palladium catalysts for cascade reactions.  Most of these compounds and complexes are both air- and moisture-sensitive, and must be handled under inert atmosphere using rigorously dried solvents.  We currently do not have the capability to adequately store and manipulate the highly reactive complexes we use daily.  A glove box with a solvent purification system is therefore essential for every aspect of this research program.