Dual-station glove box for the manipulation of sensitive synthetic intermediates

用于操作敏感合成中间体的双工位手套箱

• 批准号: 344599-2007
• 负责人: Sammis, Glenn
• 金额: $ 6.74万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2006
• 资助国家: 加拿大
• 起止时间: 2006-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=325870
• 关键词: Dual; station; glove; box; manipulation

Synthetic investigations into architecturally complex targets often lead to innovative and creative bond disconnections. Our research, therefore, uses natural products as inspiration for the development of new synthetic methodology.  This new methodology encompasses the use of organometallic reagents for the development of new bond construction techniques, the enantioselective synthesis of building blocks for total synthesis, and the development and evaluation of cascade processes for the rapid, diastereoselective synthesis of densely functionalized molecules.         Central to all of the goals of my research program is the use of highly reactive organic compounds and metal complexes, whether they are asymmetric catalysts, sensitive organic intermediates, or palladium catalysts for cascade reactions.  Most of these compounds and complexes are both air- and moisture-sensitive, and must be handled under inert atmosphere using rigorously dried solvents.  We currently do not have the capability to adequately store and manipulate the highly reactive complexes we use daily.  A glove box with a solvent purification system is therefore essential for every aspect of this research program.

对建筑复杂目标的综合研究常常导致创新和创造性的联系断裂。因此，我们的研究使用天然产物作为开发新的合成方法的灵感。这种新方法包括使用有机金属试剂开发新的键构建技术，用于全合成的对映选择性合成构建块，以及用于快速，非对映选择性合成密集功能化分子的级联过程的开发和评估。我的研究计划的核心目标是使用高活性有机化合物和金属配合物，无论是不对称催化剂，敏感有机中间体，还是级联反应的钯催化剂。大多数这些化合物和配合物都对空气和水分敏感，必须在惰性气氛下使用严格干燥的溶剂进行处理。我们目前还没有足够的能力来储存和操作我们日常使用的高反应性复合物。因此，一个带有溶剂净化系统的手套箱对于本研究计划的各个方面都是必不可少的。