High Resolution EI Mass Spectrometer

本计画旨在建立一个高解析度电子轰击质谱仪，以分析非极性有机物及有机金属化合物。质谱是一种强大的分析技术，用于识别未知化合物，定量已知化合物，并阐明分子的结构和化学性质。质谱法已被用于许多领域，包括药物发现和材料化学。它是一种分析技术，不仅应用于化学领域，而且应用于更广泛的领域。它已被合成化学家用于确认新化合物的化学合成，天然产物化学家用于天然产物的结构解析。质谱仪是一种可以测量已转化为离子的单个分子质量的仪器。它可以被看作是一台用来称量分子的机器。可以通过使用质谱仪测量质量并与化合物的理论质量匹配来鉴定化合物。不同的电离技术和质量分析仪可用于分析不同类型的化合物。非极性小分子最好通过电子碰撞（EI）电离来电离。具有电子碰撞（EI）电离源的高分辨率质谱仪对于以非常高的精度提供非极性化合物的质量测量特别有用。具有足够准确度的准确质量数据用于确认或确定化合物的元素组成（EC）。元素组成测定是合成化合物鉴定或新天然产物结构解析的关键步骤。该仪器将取代目前失效的42年前的主力仪器。新的工具是迫切需要推进PI和共同申请人以及来自UBC和该地区的其他用户的研究。该仪器将由化学系的12个研究小组和BC更广泛社区的许多其他研究小组使用。

This proposal is to obtain a high resolution EI mass spectrometer for the analysis of non-polar organic compounds and organometallics. Mass spectrometry is a powerful analytical technique that is used to identify unknown compounds, to quantify known compounds, and to elucidate the structure and chemical properties of molecules. Mass spectrometry has been used in many areas including drug discovery and material chemistry. It is an analytical technique used in not only chemistry area but very broader areas. It has been used by synthetic chemists to confirm their chemical synthesis of new compounds and natural product chemists for structure elucidation of natural products. A mass spectrometer is an instrument that can measure the masses of individual molecules that have been converted into ions. It can be viewed as a machine used to weigh molecules. A compound can be identified by measuring the mass using mass spectrometer and matching with the theoretical mass of the compound. Different ionization techniques and mass analyzers are available for analyzing different type of compounds. Non-polar small molecule are best ionized by electron impact (EI) ionization. A high resolution mass spectrometer with electron impact (EI) ionization source is particularly useful for providing mass measurements at very high accuracy for non-polar compounds. Accurate mass data with enough accuracy are used to confirm or determine the elemental composition (EC) of the compounds. Elemental composition determination is a critical step for synthetic compound identification or structure elucidation of novel natural product. This instrument will replace a 42 year old workhorse instrument that is currently failing. The new instrument is critically needed to advance the research of the PI and co-applicants as well as other users from UBC and the region. This instrument will be used by 12 research groups in the Chemistry Department and many others from broader community in BC.