Infrared-visible mueller-matrix ellipsometer

红外-可见光穆勒矩阵椭偏仪

• 批准号: 344607-2007
• 负责人: Hore, Dennis
• 金额: $ 10.9万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2006
• 资助国家: 加拿大
• 起止时间: 2006-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=325934
• 关键词: Infrared; visible; mueller; matrix; ellipsometer

The focus of our research program is to describe the molecular-level interaction between solid surfaces and biomolecules attached to these surfaces.  A better understanding of these phenomena will lead to advances in biocompatible materials for use as implants, the development of more efficient biosensors and biodiagnostic tools, and increase our fundamental knowledge of alterations to the native structure of proteins when then encounter foreign materials.  The challenge in such characterization lies in the complexity of the problem---there are many environmental factors that contribute to the biomolecules' structure on a surface. The first step towards an increased understanding is to be able to accurately describe the adsorbed structure of these molecules.  Spectroscopic techniques are among the most powerful tools for probing these structures, since they are non-invasive, non-destructive, and may probe many environments that are addressable by light.  Such methods, however, require a detailed knowledge of the the optical constants of these materials.  The infrared region offers special opportunites for structural studies since localized parts of molecules may be probed.  However, this is also the region in which optical constants are relatively unknown.  The requested instrument is an infrared-visible Mueller-matrix ellipsometer.  It will allow for a simultanous determination of a sample's thickness and complex refractive index over the complete range of wavelengths of interest for chemical identification and structural analysis.  Moreover, the proposed configuration of this state-of-the-art instrument will allow characterization of ordered molecules and rough surfaces.

我们的研究项目的重点是描述固体表面和附着在这些表面上的生物分子之间的分子水平的相互作用。更好地理解这些现象将导致生物相容性材料作为植入物的进步，更有效的生物传感器和生物诊断工具的开发，并增加我们对蛋白质天然结构改变的基本知识，当遇到外来物质时。这种表征的挑战在于，问题的复杂性-有许多环境因素影响着表面上生物分子的结构。提高理解的第一步是能够准确地描述这些分子的吸附结构。光谱技术是探测这些结构的最强大的工具之一，因为它们是非侵入性的，非破坏性的，并且可以探测许多光可寻址的环境。然而，这样的方法，需要对这些材料的光学常数有详细的了解。红外区域为结构研究提供了特殊的机会，因为可以探测分子的局部部分。然而，这也是光学常数相对未知的区域。要求的仪器是红外-可见Mueller-它将允许在感兴趣的整个波长范围内精确地确定样品的厚度和复折射率，用于化学鉴定和结构鉴定。此外，这种最先进仪器的拟议配置将允许表征有序分子和粗糙表面。