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Mechanisms of control of cell growth and proliferation by the AKT kinase family

Mechanisms of control of cell growth and proliferation by the AKT kinase family
AKT 激酶家族控制细胞生长和增殖的机制
批准号:
nhmrc : 509087
负责人:
Prof Richard Pearson
金额:
$37.9万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31

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中文摘要
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英文摘要
Ribosome synthesis and function is critical for normal cell growth and division and hence this process is exquisitely regulated. Conversely, de-regulated cell growth can lead to cancer. We have identified new roles for the AKT and SGK families of kinases in controlling this process. This proposal aims to establish the mechanisms by which these enzymes control ribosome synthesis to better understand growth control and to provide insight for targeting these pathways in growth driven cancers.
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会议论文
UNDERSTANDING THE MOLECULAR MECHANISMS CONTROLLING NUCLEOLAR SURVEILLANCE IN DISEASE
  • 批准号:
    nhmrc : 1102609
  • 项目类别:
    Project Grants
  • 资助金额:
    $58.88万
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Mechanisms of Regulation of Ribosome Biogenesis and Function in Health and Disease
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Mechanisms of Regulation of Ribosome Biogenesis and Function in Health and Disease
  • 批准号:
    nhmrc : 1058586
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $42.08万
  • 财政年份:
    2014
  • 负责人:
    Prof Richard Pearson
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Biochemical and molecular dissection of the mechanisms controlling ribosome biogenesis by the PI3K/AKT/mTOR/MYC network
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  • 项目类别:
    NHMRC Project Grants
  • 资助金额:
    $36.35万
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    2011
  • 负责人:
    Prof Richard Pearson
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