Mechanisms of control of cell growth and proliferation by the AKT kinase family

AKT 激酶家族控制细胞生长和增殖的机制

• 批准号: nhmrc : 509087
• 负责人: Prof Richard Pearson
• 金额: $ 37.9万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-control-cell-kinase-family/80793
• 关键词: Mechanisms; control; cell; growth; proliferation

Ribosome synthesis and function is critical for normal cell growth and division and hence this process is exquisitely regulated. Conversely, de-regulated cell growth can lead to cancer. We have identified new roles for the AKT and SGK families of kinases in controlling this process. This proposal aims to establish the mechanisms by which these enzymes control ribosome synthesis to better understand growth control and to provide insight for targeting these pathways in growth driven cancers.

核糖体的合成和功能对正常细胞的生长和分裂至关重要，因此这一过程受到精细的调节。相反，不受调节的细胞生长可能导致癌症。我们已经确定了AKT和SGK家族在控制这一过程中的新作用。本研究旨在建立这些酶控制核糖体合成的机制，以更好地理解生长控制，并为在生长驱动型癌症中靶向这些途径提供见解。