Mechanisms of Regulation of Ribosome Biogenesis and Function in Health and Disease

健康和疾病中核糖体生物发生和功能的调节机制

• 批准号: nhmrc : GNT1058586
• 负责人: Prof Richard Pearson
• 金额: $ 60.14万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-regulation-ribosome-health-disease/1344652
• 关键词: Mechanisms; Regulation; Ribosome; Biogenesis; Function

The PI3K/AKT signalling pathway drives many cancers and until recently was thought to do so by preventing cancer cell death. We have shown this pathway also regulates the synthesis of ribosomes, the cellular “factories” that make protein and by interfering with PI3K/AKT regulated ribosome synthesis, can kill cancer cells. We aim to establish the mechanisms underlying this regulation of ribosome synthesis and to test the hypothesis that ribosome biogenesis is a novel target for cancer treatment.

PI3K/AKT信号通路驱动了许多癌症，直到最近还被认为是通过防止癌细胞死亡来实现的。我们已经证明，这一途径也调节核糖体的合成，核糖体是制造蛋白质的细胞“工厂”，通过干扰PI3K/AKT调节的核糖体合成，可以杀死癌细胞。我们的目标是建立这种核糖体合成调控的机制，并检验核糖体生物发生是癌症治疗的新靶点的假设。