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Mechanisms of Regulation of Ribosome Biogenesis and Function in Health and Disease

Mechanisms of Regulation of Ribosome Biogenesis and Function in Health and Disease
健康和疾病中核糖体生物发生和功能的调节机制
批准号：
nhmrc : 1058586
负责人：
Prof Richard Pearson
金额：
$42.08万
依托单位：
The University of Melbourne
依托单位国家：
澳大利亚
项目类别：
Research Fellowships
财政年份：
2014
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2014-01-01 至 2018-12-31
来源：
https://researchdata.edu.au/mechanisms-regulation-ribosome-health-disease/454689
关键词：
MechanismsRegulationRibosomeBiogenesisFunction

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英文摘要
The PI3K/AKT signalling pathway drives many cancers and until recently was thought to do so by preventing cancer cell death. We have shown this pathway also regulates the synthesis of ribosomes, the cellular “factories” that make protein and by interfering with PI3K/AKT regulated ribosome synthesis, can kill cancer cells. We aim to establish the mechanisms underlying this regulation of ribosome synthesis and to test the hypothesis that ribosome biogenesis is a novel target for cancer treatment.
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会议论文
UNDERSTANDING THE MOLECULAR MECHANISMS CONTROLLING NUCLEOLAR SURVEILLANCE IN DISEASE
  • 批准号：
    nhmrc : 1102609
  • 项目类别：
    Project Grants
  • 资助金额：
    $58.88万
  • 财政年份：
    2016
  • 负责人：
    Prof Richard Pearson
  • 依托单位：
    The University of Melbourne
Mechanisms of Regulation of Ribosome Biogenesis and Function in Health and Disease
  • 批准号：
    nhmrc : GNT1058586
  • 项目类别：
    Research Fellowships
  • 资助金额：
    $60.14万
  • 财政年份：
    2014
  • 负责人：
    Prof Richard Pearson
  • 依托单位：
Biochemical and molecular dissection of the mechanisms controlling ribosome biogenesis by the PI3K/AKT/mTOR/MYC network
  • 批准号：
    nhmrc : 1004881
  • 项目类别：
    NHMRC Project Grants
  • 资助金额：
    $36.35万
  • 财政年份：
    2011
  • 负责人：
    Prof Richard Pearson
  • 依托单位：
    The University of Melbourne
Mechanisms of control of cell growth and proliferation by the AKT kinase family
  • 批准号：
    nhmrc : 509087
  • 项目类别：
    NHMRC Project Grants
  • 资助金额：
    $37.9万
  • 财政年份：
    2008
  • 负责人：
    Prof Richard Pearson
  • 依托单位：
    The University of Melbourne
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