Consortium for operation of a protein crystallographic synchrotron beamline
蛋白质晶体同步加速器光束线运行联盟
基本信息
- 批准号:217105-2006
- 负责人:
- 金额:$ 8.47万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Major Facilities Access Grants
- 财政年份:2006
- 资助国家:加拿大
- 起止时间:2006-01-01 至 2007-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Synchrotron facilities provide a source of X-ray radiation that is both highly collimated and of much greater flux than can be attained on conventional X-ray sources. These factors have greatly benefited structural biologist, enabling the elucidation of large biologically, medically and industrially important macromolecules by X-ray diffraction methods. In addition, the development of Multiwavelength Anomalous Diffraction (MAD) techniques, which demand the use of synchrotron radiation, have revolutionized macromolecular structure determinations by significantly reducing the time needed to solve a protein structure. Thus, it is not surprising that the demand for access to synchrotron facilities by protein crystallographers has dramatically increased over the last few years. Given this trend, access to synchrotron facilities has become a precious commodity. Canadian scientists whose research requires synchrotron radiation had been in a rather difficult situation since Canada did not have a synchrotron facility until recently. This situation is changing with the Canadian Light Source (CLS) opening sometime in 2006, and anticipated full operation of the first protein crystallography beamline foreseen in 2007-8. Until then, however, Canadian synchrotron-based protein crystallography research must still be conducted outside of Canada. The Multi-User Access grant application is intended to providing funding for a Canadian consortium of protein crystallographers to access synchrotron facilities. To ensure continued access, we would maintain our current participation in the operation of a protein crystallography beam line capable of performing MAD experiments at the National Synchrotron Light Source, Brookhaven National Laboratories in Upton, New York until data collection capacity sufficient to satisfy need of Canadian crystallographers is developed at CLS.
同步加速器设施提供了一种X射线辐射源,该X射线辐射源既高度准直又具有比常规X射线源所能获得的大得多的通量。这些因素使结构生物学家受益匪浅,使X射线衍射方法能够阐明生物学,医学和工业上重要的大分子。此外,需要使用同步辐射的多波长异常衍射(MAD)技术的发展,通过显着减少解决蛋白质结构所需的时间,彻底改变了大分子结构的测定。因此,蛋白质晶体学家对同步加速器设施的需求在过去几年中急剧增加也就不足为奇了。鉴于这一趋势,使用同步加速器设施已成为一种宝贵的商品。加拿大科学家的研究需要同步加速器辐射,他们的处境相当困难,因为加拿大直到最近才有同步加速器设施。这种情况正在改变与加拿大光源(CLS)在2006年的某个时候开放,并预计在2007年至2008年的第一个蛋白质晶体学光束线的全面运作。然而,在此之前,加拿大基于同步加速器的蛋白质晶体学研究仍然必须在加拿大境外进行。多用户访问赠款申请旨在为加拿大蛋白质晶体学家联盟提供资金,以访问同步加速器设施。为了确保继续获得,我们将继续参与目前在纽约厄普顿布鲁克海文国家实验室的国家同步加速器光源进行MAD实验的蛋白质晶体学光束线的操作,直到CLS开发出足以满足加拿大晶体学家需要的数据收集能力。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Sygusch, Jurgen其他文献
Active site remodeling during the catalytic cycle in metal-dependent fructose-1,6-bisphosphate aldolases
- DOI:
10.1074/jbc.ra117.001098 - 发表时间:
2018-05-18 - 期刊:
- 影响因子:4.8
- 作者:
Jacques, Benoit;Coincon, Mathieu;Sygusch, Jurgen - 通讯作者:
Sygusch, Jurgen
A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein
- DOI:
10.1074/jbc.m611505200 - 发表时间:
2007-05-11 - 期刊:
- 影响因子:4.8
- 作者:
St-Jean, Miguel;Izard, Tina;Sygusch, Jurgen - 通讯作者:
Sygusch, Jurgen
Aldolase is essential for energy production and bridging adhesin-actin cytoskeletal interactions during parasite invasion of host cells.
在寄生虫入侵宿主细胞期间,醛缩酶对于能量产生和桥接粘附素-肌动蛋白细胞骨架相互作用至关重要。
- DOI:
10.1016/j.chom.2009.03.005 - 发表时间:
2009-04-23 - 期刊:
- 影响因子:30.3
- 作者:
Starnes, G. Lucas;Coincon, Mathieu;Sygusch, Jurgen;Sibley, L. David - 通讯作者:
Sibley, L. David
Purification, crystallization and preliminary X-ray diffraction analysis of the Whirly domain of StWhy2 in complex with single-stranded DNA
- DOI:
10.1107/s1744309108032399 - 发表时间:
2008-11-01 - 期刊:
- 影响因子:0.9
- 作者:
Cappadocia, Laurent;Sygusch, Jurgen;Brisson, Normand - 通讯作者:
Brisson, Normand
Structure-Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis.
- DOI:
10.1021/acsinfecdis.6b00095 - 发表时间:
2016-10-14 - 期刊:
- 影响因子:5.3
- 作者:
Belardinelli, Juan Manuel;Yazidi, Amira;Yang, Liang;Fabre, Lucien;Li, Wei;Jacques, Benoit;Angala, Shiva Kumar;Rouiller, Isabelle;Zgurskaya, Helen I.;Sygusch, Jurgen;Jackson, Mary - 通讯作者:
Jackson, Mary
Sygusch, Jurgen的其他文献
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{{ truncateString('Sygusch, Jurgen', 18)}}的其他基金
Structural investigation of reaction intermediates in glycolytic aldolases
糖酵解醛缩酶反应中间体的结构研究
- 批准号:
RGPIN-2016-04898 - 财政年份:2021
- 资助金额:
$ 8.47万 - 项目类别:
Discovery Grants Program - Individual
Structural investigation of reaction intermediates in glycolytic aldolases
糖酵解醛缩酶反应中间体的结构研究
- 批准号:
RGPIN-2016-04898 - 财政年份:2020
- 资助金额:
$ 8.47万 - 项目类别:
Discovery Grants Program - Individual
Structural investigation of reaction intermediates in glycolytic aldolases
糖酵解醛缩酶反应中间体的结构研究
- 批准号:
RGPIN-2016-04898 - 财政年份:2019
- 资助金额:
$ 8.47万 - 项目类别:
Discovery Grants Program - Individual
Structural investigation of reaction intermediates in glycolytic aldolases
糖酵解醛缩酶反应中间体的结构研究
- 批准号:
RGPIN-2016-04898 - 财政年份:2018
- 资助金额:
$ 8.47万 - 项目类别:
Discovery Grants Program - Individual
Structural investigation of reaction intermediates in glycolytic aldolases
糖酵解醛缩酶反应中间体的结构研究
- 批准号:
RGPIN-2016-04898 - 财政年份:2017
- 资助金额:
$ 8.47万 - 项目类别:
Discovery Grants Program - Individual
Structural investigation of reaction intermediates in glycolytic aldolases
糖酵解醛缩酶反应中间体的结构研究
- 批准号:
RGPIN-2016-04898 - 财政年份:2016
- 资助金额:
$ 8.47万 - 项目类别:
Discovery Grants Program - Individual
Structural investigation of reaction intermediates in glycolytic aldolases
糖酵解醛缩酶反应中间体的结构研究
- 批准号:
41723-2010 - 财政年份:2014
- 资助金额:
$ 8.47万 - 项目类别:
Discovery Grants Program - Individual
Structural investigation of reaction intermediates in glycolytic aldolases
糖酵解醛缩酶反应中间体的结构研究
- 批准号:
41723-2010 - 财政年份:2013
- 资助金额:
$ 8.47万 - 项目类别:
Discovery Grants Program - Individual
Structural investigation of reaction intermediates in glycolytic aldolases
糖酵解醛缩酶反应中间体的结构研究
- 批准号:
41723-2010 - 财政年份:2012
- 资助金额:
$ 8.47万 - 项目类别:
Discovery Grants Program - Individual
Structural investigation of reaction intermediates in glycolytic aldolases
糖酵解醛缩酶反应中间体的结构研究
- 批准号:
41723-2010 - 财政年份:2011
- 资助金额:
$ 8.47万 - 项目类别:
Discovery Grants Program - Individual
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Consortium for the operation of protein crystallographic microfocus synchrotron beamline
蛋白质晶体学微焦点同步加速器光束线运行联盟
- 批准号:
217105-2009 - 财政年份:2008
- 资助金额:
$ 8.47万 - 项目类别:
Major Resources Support Program - Infrastructure
Consortium for operation of a protein crystallographic synchrotron beamline
蛋白质晶体同步加速器光束线运行联盟
- 批准号:
217105-2006 - 财政年份:2008
- 资助金额:
$ 8.47万 - 项目类别:
Major Facilities Access Grants
Consortium for operation of a protein crystallographic synchrotron beamline
蛋白质晶体同步加速器光束线运行联盟
- 批准号:
217105-2006 - 财政年份:2007
- 资助金额:
$ 8.47万 - 项目类别:
Major Facilities Access Grants
Consortium for operation of a protein crystallographic synchrotron beamline
蛋白质晶体同步加速器光束线运行联盟
- 批准号:
217105-2003 - 财政年份:2005
- 资助金额:
$ 8.47万 - 项目类别:
Major Facilities Access Grants