Black Death genomics and the evolution of pathogen virulence

黑死病基因组学和病原体毒力的进化

• 批准号: nhmrc : 1065106
• 负责人: Prof Edward Holmes
• 金额: $ 35.03万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/black-death-genomics-pathogen-virulence/455152
• 关键词: Black; Death; genomics; evolution; pathogen

The Black Death was one of the most lethal plagues of antiquity and changed the course of human history. We will reconstruct and analyse the evolution of its causative agent – the bacterium Yersinia pestis – sampled from human skeletal remains dating back to the Black Death and beyond. We will determine the mutations that changed the virulence of plague epidemics through time, enabling a unique insight into the most dramatic example of pathogen emergence that has ever been available for study.

黑死病是古代最致命的瘟疫之一，改变了人类历史的进程。我们将重建和分析其病原体的进化-鼠疫耶尔森氏菌-从人类骨骼遗骸中取样，可追溯到黑死病及以后。我们将确定随着时间的推移改变鼠疫流行病毒力的突变，从而对迄今为止可用于研究的病原体出现的最引人注目的例子进行独特的见解。