Revealing the evolutionary and ecological dynamics of avian influenza virus

揭示禽流感病毒的进化和生态动力学

• 批准号: DP160102146
• 负责人: Prof Edward Holmes
• 金额: $ 37.34万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-06-29
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160102146
• 关键词: Revealing; evolutionary; ecological; dynamics; avian

This project aims to understand how avian influenza virus (AIV) emerges, evolves and spreads in wild birds. AIV has the potential to devastate the poultry industry and cause human pandemics, but the factors that shape the genetic diversity of AIV in its wild bird reservoir are poorly understood. The project plans to combine genomic, ecological and phylogenetic approaches to reveal key aspects of AIV evolution, as well as the risk for future viral emergence. Using sampling sites in Australia and Antarctica, it plans to investigate AIV diversity, the evolutionary dynamics of AIV in wild birds and poultry, and the role played by environmental transmission in AIV ecology.

该项目旨在了解禽流感病毒（AIV）如何在野生鸟类中出现、演变和传播。禽流感病毒有可能摧毁家禽业并导致人类流行病，但是在其野生鸟类宿主中形成禽流感病毒遗传多样性的因素知之甚少。该项目计划结合基因组学、生态学和系统发育方法，揭示AIV进化的关键方面，以及未来病毒出现的风险。利用澳大利亚和南极洲的采样点，计划调查AIV的多样性、野生鸟类和家禽中AIV的进化动态以及环境传播在AIV生态中的作用。