The genetic basis of pathogen blocking: elucidating the contributions of the Wolbachia, dengue virus and mosquito genomes

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A bacterium called Wolbachia has been shown to stop dengue virus from replicating inside mosquitoes and so is being field-tested as a biocontrol agent against dengue fever. A major threat to this strategy is the emergence of resistance either in the mosquito or virus. This proposal addresses two fundamental knowledge gaps – how does Wolbachia block virus growth and how might resistance evolve? This research is significant as it will inform the development of strategies to counter resistance.