Blood biomarkers for the diagnosis of pre-clinical Alzheimer’s disease employing the Dominantly Inherited Alzheimer Network cohort

利用显性遗传性阿尔茨海默病网络队列诊断临床前阿尔茨海默病的血液生物标志物

• 批准号: nhmrc : 1129627
• 负责人: A/Pr Mark Molloy
• 金额: $ 76.92万
• 依托单位: Edith Cowan University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/blood-biomarkers-diagnosis-network-cohort/948421
• 关键词: Blood; biomarkers; diagnosis; pre; clinical

Alzheimer’s disease (AD) is the most common form of dementia and yet a postmortem examination serves as the only definitive diagnosis. The current proposal seeks to investigate alterations in biochemical profiles of individuals who will develop Alzheimer’s disease due to an inherited mutation, against family members who are non-carriers of the mutation, to identify AD related blood changes which can contribute towards the development of a diagnostic blood test for the disease.

阿尔茨海默病(AD)是痴呆症最常见的形式，但尸检是唯一确定的诊断。目前的建议旨在调查由于遗传突变而患上阿尔茨海默氏症的个人相对于非突变携带者的家庭成员的生化特征的变化，以确定与AD相关的血液变化，这可能有助于开发一种诊断该疾病的血液测试。