BovB: Jumping the fine LINE between species

BovB：跨越物种之间的界限

• 批准号: Local : table=study+id=8
• 金额: --
• 依托单位国家: 澳大利亚
• 资助国家: 澳大利亚
• 起止时间: 0100-11-30 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/bovb-jumping-fine-line-species/60514
• 关键词: BovB; Jumping; fine; LINE; between

In higher organisms such as vertebrates, it is generally believed that lateral transfer of genetic information does not readily occur, with the exception of retroviral infection. However, horizontal transfer (HT) of protein coding repetitive elements is the simplest way to explain the patchy distribution of BovB, a LINE (Long Interspersed Nuclear Element) about 3.2kb long, that has been found in ruminants, marsupials, squamates, monotremes and African mammals. BovB sequnces are a major component of some of these genomes. Here we show that HT of BovB is significantly more widespread than believed, and we demonstrate for the first time the existence of two plausible arthropod vectors, specifically reptile ticks. A phylogenetic tree built from BovB sequences from species in all of these groups does not conform to expected evolutionary relationships of the species, and our analysis indicates that at least 9 HT events are required to explain the observed topology. Our results provide compelling evidence from HT of genetic material that has transformed vertebrate genomes.

一般认为，在脊椎动物等高等生物中，除了逆转录病毒感染外，遗传信息的横向转移不容易发生。然而，编码重复元件的蛋白质的水平转移（HT）是解释BovB的斑块分布的最简单的方法，BovB是一种长约3.2kb的LINE (Long Interspersed Nuclear Element)，已在反刍动物、有袋动物、有鳞动物、单孔目动物和非洲哺乳动物中发现。BovB序列是其中一些基因组的主要组成部分。在这里，我们表明BovB的HT比想象的要广泛得多，我们首次证明了两种可能的节肢动物载体的存在，特别是爬行动物蜱。从所有这些类群中物种的BovB序列构建的系统发育树不符合物种的预期进化关系，我们的分析表明至少需要9个HT事件来解释观察到的拓扑结构。我们的研究结果提供了令人信服的证据，证明遗传物质已经改变了脊椎动物的基因组。