Cell Death and Inflammation

细胞死亡和炎症

• 批准号: nhmrc : GNT1141466
• 负责人: Dr James Vince
• 金额: $ 47.67万
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cell-death-inflammation/1348378
• 关键词: Cell; Death; Inflammation

The pathology of many acute and chronic diseases associated with the inappropriate activation of genetically encoded programmed cell death pathways, such as sepsis, stroke, diabetes and neurodegeneration, is linked to detrimental inflammation. This project will accurately define at the molecular level how programmed cell death triggers inflammatory responses, and use this knowledge to test novel and next-generation therapeutic strategies in inflammatory-driven diseases.

与遗传编码的程序性细胞死亡途径的不适当激活相关的许多急性和慢性疾病的病理学，如败血症、中风、糖尿病和神经变性，与有害的炎症有关。该项目将在分子水平上准确定义程序性细胞死亡如何触发炎症反应，并利用这些知识来测试炎症驱动疾病的新一代治疗策略。