Cell Survival Pathways as Potential Targets in Breast Cancer

细胞生存途径作为乳腺癌的潜在靶点

• 批准号: nhmrc : 1094320
• 金额: $ 9.53万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cell-survival-pathways-breast-cancer/519479
• 关键词: Cell; Survival; Pathways; Potential; Targets

Cancer cells are characterised by their capacity for relentless growth, survival and evasion of cell death. This proposal will use patient derived xenograft models of primary breast cancer to test the hypothesis that addition of BH3-mimetics could improve response to anti-HER2 therapy. This technique involves transplantation of patient tumours into immune-compromised mice. This represents a useful method for testing new agents.

癌细胞的特点是具有持续生长、存活和逃避细胞死亡的能力。该提案将使用源自患者的原发性乳腺癌异种移植模型来测试添加 BH3 模拟物可以改善抗 HER2 治疗反应的假设。该技术涉及将患者肿瘤移植到免疫受损的小鼠体内。这代表了测试新药物的有用方法。