Cell Survival Pathways as Potential Targets in Breast Cancer
Cell Survival Pathways as Potential Targets in Breast Cancer
细胞生存途径作为乳腺癌的潜在靶点
批准号：
nhmrc : 1094320
负责人：
金额：
$9.53万
依托单位国家：
澳大利亚
项目类别：
Postgraduate Scholarships
财政年份：
2015
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2015-01-01 至 2018-12-31
中文摘要
翻译
癌细胞的特点是它们能够持续生长、存活和逃避细胞死亡。这项建议将使用患者来源的原发性乳腺癌异种移植模型来检验添加BH3-模拟物可以改善对抗HER2治疗的反应的假设。这项技术涉及将患者的肿瘤移植到免疫受损的小鼠身上。这是一种测试新代理的有用方法。
英文摘要
Cancer cells are characterised by their capacity for relentless growth, survival and evasion of cell death. This proposal will use patient derived xenograft models of primary breast cancer to test the hypothesis that addition of BH3-mimetics could improve response to anti-HER2 therapy. This technique involves transplantation of patient tumours into immune-compromised mice. This represents a useful method for testing new agents.
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