Cell swelling and EEG ripples: components in the transformation of normal brain activity into seizure

细胞肿胀和脑电图波纹：正常大脑活动转变为癫痫发作的组成部分

• 批准号: nhmrc : 595948
• 负责人: A/Pr (Claude) William Shuttleworth
• 金额: $ 24.68万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cell-swelling-eeg-activity-seizure/82631
• 关键词: Cell; swelling; EEG; ripples; components

Epilepsy is a highly debilitating conditioned and seizures are often poorly controlled. Using a novel multidisciplinary approach, the aim of this proposal is to define the participation of cell swelling and nerve cell brain activity during the start and spread of seizures. This research introduces a novel seizure induction mechanism and provides a paradigm shift in focus for epilepsy research, as well as suggests new pharmacologic targets for seizure-intervention.

癫痫是一种高度衰弱的条件性疾病，癫痫发作往往控制不佳。使用一种新的多学科方法，该提案的目的是定义癫痫发作开始和蔓延期间细胞肿胀和神经细胞脑活动的参与。这项研究介绍了一种新的癫痫发作诱导机制，为癫痫研究提供了一个范式转变，并为癫痫干预提供了新的药理学靶点。