Cell swelling and EEG ripples: components in the transformation of normal brain activity into seizure

癫痫是一种高度衰弱的条件性疾病，癫痫发作往往控制不好。使用一种新的多学科方法，这项建议的目的是确定细胞肿胀和神经细胞脑活动在癫痫发作开始和蔓延过程中的参与。这项研究介绍了一种新的癫痫诱导机制，为癫痫研究提供了一个范式转移，并为癫痫干预提供了新的药理靶点。

Epilepsy is a highly debilitating conditioned and seizures are often poorly controlled. Using a novel multidisciplinary approach, the aim of this proposal is to define the participation of cell swelling and nerve cell brain activity during the start and spread of seizures. This research introduces a novel seizure induction mechanism and provides a paradigm shift in focus for epilepsy research, as well as suggests new pharmacologic targets for seizure-intervention.