Cell therapy to prevent and treat graft-versus-host disease after allogeneic haematopoietic stem cell transplantation

细胞疗法预防和治疗异基因造血干细胞移植后移植物抗宿主病

• 批准号: nhmrc : 1054786
• 负责人: Dr Siok-Keen Tey
• 金额: $ 17.36万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cell-therapy-prevent-cell-transplantation/112419
• 关键词: Cell; therapy; prevent; treat; graft

In bone marrow transplantation, donor immunity can fight the cancer but can also attack healthy tissues, causing graft-versus-host disease (GVHD). We will use two types of cell therapy to treat GVHD. The first study will use a safety switch called inducible capase 9 (iCasp9) to enable the donor immune cells to be rapidly eliminated if GVHD occurs. The second study will use regulatory T cells to treat patients with chronic GVHD. If successful, these treatment approaches will make transplantation safer.

在骨髓移植中，供者免疫可以对抗癌症，但也可以攻击健康组织，导致移植物抗宿主病(GVHD)。我们将使用两种细胞疗法来治疗GVHD。第一项研究将使用一种名为可诱导Capase 9(ICasp9)的安全开关，使捐赠者的免疫细胞能够在发生GVHD时被迅速消除。第二项研究将使用调节性T细胞治疗慢性移植物抗宿主病患者。如果成功，这些治疗方法将使移植更安全。