Ionic liquids supported synthesis

与普通有机溶剂相比，离子液体具有一些耐人寻味的特性：高的热稳定性和化学稳定性，几乎不可测量的蒸汽压，不可燃性，减摩，抗磨性能和高负载能力。许多化学反应，包括一些酶反应，可以在离子液体中进行。室温离子液体也被探索为化学提取和其他工业过程的环境友好介质。在许多情况下，离子液体可以进行许多化学反应，包括一些酶反应。离子液体可以很容易地回收利用。离子液体的一个吸引人的特点是它们的溶解度可以很容易地调节，因此它们可以根据阳离子和阴离子的选择而从有机和水介质中分离出来。底物的溶解度也可以调节。这表明利用这些低分子离子液体作为有机合成的可溶性载体是可能的。离子液体相、有机相和水相之间可以实现相分离以进行产物的分离和纯化。在这项拟议的研究中，我们打算展示离子液体支撑合成(ILSS)合成小分子、寡肽、寡糖、寡核苷酸和糖肽的一般策略。此外，我们还将展示利用离子液体支撑的硫化合物作为一种减少挥发性有机硫化合物气味的方法。此外，还将进行离子液体支撑的有机催化剂的探索。

Relative to common organic solvents, ionic liquids have some intriguing properties: high thermal and chemical stability, nearly no measurable vapor pressure, non-flammability, friction reduction, anti-wear performance and high loading capacity.  Numerous chemical reactions, including some enzymic reactions, can be carried out in ionic liquids.  Room temperature ionic liquids have also been explored as environmentally benign media for chemical extractions and other industrial processes.  In many cases, the ionic liquids can be recycled easily.  An attractive feature of ionic liquids is that their solubilities can be tuned readily so that they can phase separate from organic as well as aqueous media depending on the choice of cations and anions. Substrate solubility can also be tuned. This suggests the possibility of using these low molecular weight ionic liquids as soluble supports for organic synthesis.  Phase separation between the "ionic liquid phase", the organic phase, and the aqueous phase can be achieved for product separation and purification.  In this proposed research, we intend to demonstrate the general strategy of ionic liquid support synthesis (ILSS) for the synthesis of small molecules, oligopeptides, oligosaccharides, oligonucleotides, and glycopeptides.  In addition, we will demonstrate the use ionic liquid supported sulfur compounds as a way to reduce the odor of volatile organosulfur compounds.  The exploration of ionic liquid supported organocatalysts will also be carried out.