Ionic-liquid-supported synthesis

离子液体支持合成

• 批准号: 3769-2007
• 负责人: Chan, TakHang
• 金额: $ 2.19万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=449582
• 关键词: Ionic; liquid; supported; synthesis

In this proposal, it is suggested that soluble ionic liquids can be used as supports for catalyst/reagent immobilization and synthesis in homogeneous solution phase. Because of the wide range of ionic liquid supports available, their use as supports is likely to be compatible with most common synthetic chemistries. The solubility properties of these ionic liquid supports can be tuned by the variation of cations and anions to make them phase separate from less polar organic solvents and aqueous media. The ionic liquid-supported species can therefore be purified from the reaction mixture by simple washings. Ionic liquid-supported catalysts and reagents will be prepared and used and reused. Parallel and combinatorial libraries of small molecules have been synthesized. Ionic liquid-supported synthesis (ILSS) will applied to the preparation of peptides, oligosaccharides and oligonucleotides. The comparison of ILSS with solid-phase synthesis, soluble-polymer supported synthesis and fluorous phase synthesis will be highlighted where applicable.

本提案建议可溶性离子液体可用作均相溶液相催化剂/试剂固定和合成的载体。 由于可获得的离子液体载体范围广泛，它们作为载体的用途可能与大多数常见的合成化学相容。 这些离子液体载体的溶解度性质可以通过阳离子和阴离子的变化来调节，以使它们与极性较小的有机溶剂和水性介质相分离。 因此，离子液体负载的物质可以通过简单的洗涤从反应混合物中纯化。 离子液体负载的催化剂和试剂将被制备和使用并重复使用。 已经合成了小分子的平行和组合文库。 离子液体支持的合成技术将被应用于多肽、寡糖和寡核苷酸的制备。 ILSS与固相合成，可溶性聚合物支持的合成和氟相合成的比较将突出在适用的情况下。