Characterization of casein phosphopeptide amorphous calcium fluoride phosphate as a remineralization system

酪蛋白磷酸肽无定形氟化钙磷酸盐作为再矿化系统的表征

• 批准号: nhmrc : 400299
• 负责人: Dr Joseph Palamara
• 金额: $ 32.91万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterization-casein-phosphopeptide-phosphate-remineralization/99791
• 关键词: Characterization; casein; phosphopeptide; amorphous; calcium

Dental caries (tooth decay) remains a major public health problem in Australia with an economic burden in excess of $1 billion p.a. The overall aim of this project is the development of a novel remineralizing agent (casein phosphopeptide stabilized amorphous calcium fluoride phosphate) for the remineralization of early tooth decay lesions (white spot lesions). The project will involve the testing of the ability of the novel remineralization system to remineralize (repair) white spot lesions in vitro and in situ. The project also involves the detailed characterization of the molecular interactions of the components of the remineralizing system using NMR spectroscopy and other techniques. It is anticipated that this project will result in the development of a system with substantialy superior properties for the non-invasive treatment (reversal) of white spot lesions and may ultimately lead to the development of a novel system for the treatment and prevention of tooth decay.

龋齿（蛀牙）仍然是澳大利亚的一个主要公共卫生问题，每年的经济负担超过10亿澳元。该项目的总体目标是开发一种新型的矿化剂（酪蛋白磷酸肽稳定的无定形磷酸氟化钙），用于早期蛀牙病变（白色斑点病变）的矿化。该项目将涉及测试新型再生系统在体外和原位再生（修复）白色斑点病变的能力。该项目还涉及使用NMR光谱学和其他技术详细表征生物矿化系统组分的分子相互作用。预计该项目将导致开发出一种系统，该系统具有用于白色斑点病变的非侵入性治疗（逆转）的显著上级特性，并可能最终导致开发出一种用于治疗和预防蛀牙的新型系统。