Characterization of the Type IX secretion system in Porphyromonas gingivalis

牙周炎与主要病原体牙龈卟啉单胞菌有关。我们在牙龈假单胞菌中发现了一种由至少12种成分组成的新型蛋白质分泌机器，它将细菌的主要毒力因子运送到细胞表面并将它们附着在外膜上。我们的目标是确定这12个组成部分的空间排列和具体作用，从而为未来治疗这种疾病提供目标。

Periodontitis is associated with the keystone pathogen Porphyromonas gingivalis. We have identified a novel protein secretion machine comprised of at least 12 components in P. gingivalis which transports the bacterium's major virulence factors to the cell surface and attaches them to the outer membrane. We aim to determine the spatial arrangement and specific role of each of these 12 components and thereby provide targets for future treatments against this disease.