Chemokine and chemokine receptor regulation of T lymphocyte traffic to lymph nodes

趋化因子和趋化因子受体对 T 淋巴细胞向淋巴结运输的调节

• 批准号: nhmrc : 113906
• 负责人: Prof Andrew Lloyd
• 金额: $ 13.05万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/chemokine-chemokine-receptor-lymph-nodes/99979
• 关键词: Chemokine; chemokine; receptor; regulation; lymphocyte

The movement of white blood cells from the bloodstream into the tissues is a key component of how we defend ourselves against infection and cancer, and also develop unwanted illnesses such as allergy. In particular, the migration of cells into lymph nodes is a critical step in the development of an efficient immune response. Surprisongly little is known about the control of this important cell trafficking process. In this research, the signals that control the movement of white blood cells are being studied, notably a specialised family of immunological hormones, known as chemokines. Our initial studies suggest that chemokines are indeed the factors which control the traffic of the most important cell type - T cells, into lymph nodes. This research will examine how the activity of specific chemokines controls the influx of particular groups of T cells and subsequently determines the characteristics of the overall immune response taking place in the lymph node.

白色血细胞从血流进入组织的运动是我们如何保护自己免受感染和癌症的关键组成部分，也会发展出过敏等不必要的疾病。特别是，细胞迁移到淋巴结中是有效免疫应答发展的关键步骤。令人惊讶的是，对这一重要的细胞贩运过程的控制知之甚少。在这项研究中，控制白色血细胞运动的信号正在被研究，特别是一个专门的免疫激素家族，称为趋化因子。我们的初步研究表明，趋化因子确实是控制最重要的细胞类型- T细胞进入淋巴结的因素。这项研究将研究特定趋化因子的活性如何控制特定T细胞群的流入，并随后确定淋巴结中发生的整体免疫反应的特征。