A Randomised Double Blind, Placebo-controlled Study of Nefiracetam in Patients with Post- stroke Apathy

奈非拉西坦治疗中风后冷漠患者的随机双盲、安慰剂对照研究

• 批准号: nhmrc : 634412
• 负责人: A/Pr Wendy Davis
• 金额: $ 57.7万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/randomised-double-blind-stroke-apathy/76056
• 关键词: Randomised; Double; Blind; Placebo; controlled

A wide range of emotional and cognitive disturbances are observed following stroke. Apathy is expressed by diminished initiation and poor persistence on tasks, lack of interest, emotional indifference and low social engagement. Our preliminary study has suggested that the medication nefiracetam significantly improves apathy among stroke patients. The main aim of our project is to conduct a large scale study to determine whether nefiracetam improves apathy in patients with stroke lesions.

中风后会观察到广泛的情绪和认知障碍。冷漠表现为主动性减弱，对任务的坚持性差，缺乏兴趣，情绪冷漠，社交参与度低。我们的初步研究表明，药物奈非西坦显著改善了中风患者的冷漠。我们项目的主要目的是进行一项大规模研究，以确定奈非拉西坦是否能改善中风患者的冷漠。