Regulation of the actin cytoskeleton by miR-200

miR-200 对肌动蛋白细胞骨架的调节

• 批准号: nhmrc : 1008327
• 负责人: A/Pr Andrew Ruszkiewicz
• 金额: $ 36.03万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-actin-cytoskeleton-mir-200/109303
• 关键词: Regulation; actin; cytoskeleton; miR; 200

The migration of cancer cells (metastasis) is responsible for most cancer deaths. Central to this is dynamic organisation of the actin cytoskeleton _ an internal structure that provides cell shape and enables movement. We have identified a family of small molecules (called miR-200) that regulates this actin cytoskeleton through specifically downregulating various genes. We are investigating the nature of these genes and their role in cell motility _ an underlying pre-requisite of metastasis.

癌细胞的迁移（转移）是大多数癌症死亡的原因。其核心是肌动蛋白细胞骨架的动态组织--一种提供细胞形状并使其运动的内部结构。我们已经确定了一个小分子家族（称为miR-200），通过特异性下调各种基因来调节这种肌动蛋白细胞骨架。我们正在研究这些基因的性质及其在细胞运动中的作用-转移的基本先决条件。