Molecular characterisation of early precursor lesions of a novel ñserrated pathwayî of colorectal cancer using gene expression and proteomics.

使用基因表达和蛋白质组学对结直肠癌新型“锯齿状通路”的早期前体病变进行分子表征。

• 批准号: nhmrc : 1012157
• 负责人: A/Pr Andrew Ruszkiewicz
• 金额: $ 21.23万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-characterisation-early-expression-proteomics/109637
• 关键词: Molecular; characterisation; early; precursor; lesions

In Australia, CRC is the second highest cause of all cancer-related deaths. If detected early, CRC has a high success rate of cure, but a percentage of precursor lesions escape detection and show aggressive clinical behaviour to progress to CRC. These are difficult to diagnosis with existing technologies. We aim to understand the biology behind sessile serrated adenoma pathways and hence enhance early detection, diagnosis and treatments strategies.

在澳大利亚，结直肠癌是所有癌症相关死亡的第二大原因。如果早期发现，结直肠癌有很高的治愈成功率，但一定比例的前驱病变未被发现，并表现出积极的临床行为，进展为结直肠癌。现有技术很难诊断这些疾病。我们的目的是了解背后的生物学无柄锯齿状腺瘤途径，从而提高早期发现，诊断和治疗策略。