Regulation of expression of the microRNA-200 family

microRNA-200 家族表达的调控

• 批准号: nhmrc : 508089
• 负责人: A/Pr Andrew Ruszkiewicz
• 金额: $ 38.24万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-expression-microrna-200-family/76472
• 关键词: Regulation; expression; microRNA; 200; family

The majority of deaths from cancer are due to tumour metastasis. To metastasize, tumour cells must convert to a migratory form that can allow tumor cells to migrate and disseminate in the body. This process requires a genetic reprogramming of the cell. We have discovered that this genetic reprogramming is under the control of small RNA molecules called microRNAs. In this project we investigate what controls the levels of the microRNAs, to allow metastasis to occur in colon tumours.

大多数癌症死亡是由于肿瘤转移。为了转移，肿瘤细胞必须转化为迁移形式，允许肿瘤细胞在体内迁移和扩散。这个过程需要细胞的基因重编程。我们已经发现这种基因重编程是在称为microRNA的小RNA分子的控制下进行的。在这个项目中，我们研究了是什么控制了microRNA的水平，使结肠肿瘤发生转移。