Defining the function of ROCK in establishing a tumour-promoting microenvironment

定义ROCK在建立促肿瘤微环境中的功能

• 批准号: nhmrc : 1103712
• 负责人: A/Pr Andrew Ruszkiewicz
• 金额: $ 41.93万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-function-rock-promoting-microenvironment/662690
• 关键词: Defining; function; ROCK; establishing; tumour

Cancer’s spread from its primary to secondary sites causes most cancer-related deaths. As cancers grow and spread, their internal structure is modified. Immune cells within the cancer begin to behave differently to the same types of cells in normal tissues, promoting its spread. We have discovered that many of these changes are regulated by a protein called ROCK. We plan to study how ROCK controls such a wide range of tumour promoting processes.

癌症从原发部位扩散到继发部位，导致了大多数与癌症相关的死亡。随着癌症的生长和扩散，其内部结构也会发生改变。癌细胞内的免疫细胞开始表现出与正常组织中相同类型的细胞不同的行为，从而促进其扩散。我们发现，这些变化中的许多都是由一种名为ROCK的蛋白质调节的。我们计划研究岩石如何控制如此广泛的肿瘤促进过程。