Biosafety cabinet for surface modification of quantum dots to preconcentrate trace prion protein selectively from biological fluids

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My research program will continue with the development of affinity probes, especially molecularly imprinted polymers (MIPs), in biomedical applications for both the improvement to human health care and the early diagnosis of animal diseases.  Abnormal prion protein (PrPSc) associated with transmissible spongiform encephalopathies (TSEs) probably present a serious and demonstrable risk to food safety and public health worldwide.  The determination of PrPSc at ultratrace levels is most promising by selective pre-concentration using the molecular recognition property of a tailor-made MIP.  For the determination of several abnormal proteins simultaneously after selective pre-concentration on MIPs, capillary electrophoresis and microfluidics can offer many analytical separation merits.  Our short-term objective is focused on the preparation of novel MIP nanospheres which can specifically recognize single target proteins of biomedical significance.  Key contemporary and emerging challenges in analytical sciences will be tackled using MIP nanospheres-based methods in an advanced instrumental approach.  Our long-term objective is escalating the development of powerful MIP nanospheres-based devices, instruments, methods, facilities and expertise that will one day contribute to biomedical research in collaboration with science departments, government laboratories and research hospitals in Ottawa and across Canada.