300 MHz NMR spectrometer for "walk on" use in chemistry research at the University of Winnipeg

温尼伯大学化学研究中“步行”使用的 300 MHz NMR 波谱仪

• 批准号: 360318-2008
• 负责人: Ata, Athar
• 金额: $ 7.1万
• 依托单位: University of Winnipeg
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=363520
• 关键词: 300; MHz; NMR; spectrometer; walk

Natural products derived from marine and terrestrial sources exhibit interesting anti-microbial, anti-viral and anti-inflammatory activities. These bioactivities make natural products as an important source for the discovery of new pharmaceutical agents and more than 60% of the drugs available on the market are of natural product origin. For instance, Taxol, isolated from pacific yew tree Taxus brevifolia, is a potent anti-cancer agent. One of the most important steps in this research involves the structure elucidation of bioactive natural products. Nuclear Magnetic Resonance (NMR) spectrometer is one of the required tools to acquire one- and two-dimensional spectral data (1H-, 13C, COSY, TOCSY, HMQC, HMBC, NOESY) used in the structure elucidation of complex chemical compounds. This chemical characterization helps in designing the synthesis of newly isolated bioactive natural products. This machine is also used to study the reaction mechanisms in inorganic and organic chemistry. It is considered as one of the most important instruments in chemistry departments to facilitate the structural characterization of chemical compounds.  The Department of Chemistry, University of Winnipeg no longer has a  functional NMR available.  Therefore, we are requesting funds to acquire a 300 MHz NMR to facilitate our various NSERC funded research programs.

来自海洋和陆地的天然产物具有有趣的抗微生物、抗病毒和抗炎活性。这些生物活性使天然产物成为发现新药的重要来源，市场上60%以上的药物都是天然产物来源。例如，从太平洋红豆杉中分离出的紫杉醇就是一种有效的抗癌剂。在这一研究中最重要的步骤之一是生物活性天然产物的结构阐明。核磁共振波谱仪是复杂化合物结构解析中获取一维和二维光谱数据（1H-、13C、COSY、TOCSY、HMQC、HMBC、NOESY）的必备工具之一。这种化学特性有助于设计新分离的生物活性天然产物的合成。本机也用于研究无机化学和有机化学中的反应机理。它被认为是化学部门最重要的仪器之一，以方便化合物的结构表征。温尼伯大学化学系不再有功能核磁共振可用。因此，我们正在申请获得300 MHz核磁共振的资金，以促进我们的各种NSERC资助的研究项目。