Regulation of endogenous heart regeneration by an anti-fibrotic microRNA.

与成年人的心脏不同，新生儿的心脏在心脏病发作后没有疤痕愈合。调控新生哺乳动物心脏再生的分子机制尚不完全清楚。当前研究的目标是确定最近发现的被称为microrna的分子家族在调节无疤痕愈合中的作用。我们提出了一种新的策略来重新激活成人心脏中的microrna，以促进心脏病发作后的再生。

In contrast to the adult heart, the newborn heart undergoes scarless healing following a heart attack. The molecular mechanisms that govern heart regeneration in newborn mammals are not fully understood. The goal of the current study is to determine the role of a recently identified family of molecules known as microRNAs in the regulation of scarless healing. We propose a novel strategy for re-activation of microRNAs in the adult heart to promote regeneration following heart attack.