Surface-coated metal nanoparticles with carbohydrate polymers as

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Surface coated metal nanoparticles as therapeutic delivery agents are revolutionizing biomedical technologies. Currently there are several approaches being developed for cell-specific targeting of nanoparticles from systemic administration, but the fate of these particles inside the cell/body is often not well controlled. Our research focuses on developing advanced multifunctional nano-based materials that overcome transport limitations in tissues and within cells. Our goal is to prepare surface coated metal nanoparticles with well-defined carbohydrate polymers for improved solubility and stability (less aggregation in complex mixture), more resistance to surface adsorption, prolonged circulation time in bloodstream, reduced protein and cell adherence, reduced toxicity and reduced foreign body response in tissues.