Chemistry of conjugated lipids

合成有机化学产生了改变植物油性质的方法，许多方法是众所周知的，但很少有方法可以廉价地应用于工业实践。因此，有必要将这些过程简化为实践，以生产各种增值的消费和工业产品。这项提议的方法是开发更有效的工业工艺，将植物油转化为改进的消费和工业产品。新合成中使用的植物油将从加拿大具有独特化学和/或低成本的作物中提取，包括油菜籽、亚麻、高油酸油菜籽、索林亚麻、香菜、山茶油和油菜籽。这些改性油将进行相关的化学和物理特性测试，但这项研究的目的不是开发新产品。新产品的制定将由一系列加拿大公司和大学合作者进行，他们目前正在研究和开发新产品。当开发出有效的合成和浓缩方法时，将制备出足够供合作者评估的大量产品。这一实物或现金捐助将通过合作单独提供。将开发新的工艺，以将植物油廉价地转化为以下产品：1)在低温(-40℃)下保持液体；2)具有低粘度(&lt；4 CP)；3)具有高粘度(&gt；200 CP)；具有高极性；4)具有低极性；5)具有增强的氧化稳定性(&gt；10 h AOM)。申请人已经开发了用于工业应用的制备烷基酯和共轭脂肪酸的专利方法和商业秘密。该项目将培养博士和理科硕士。考生和暑期学生。在探索Diels-Alder化学和脂类性质的改性时，学生将由一位在工业工艺设计和知识产权保护方面具有丰富经验的导师指导。

Synthetic organic chemistry yields routes to change the properties of plant oils and many are well known but few of the processes can be made inexpensive enough to be applied to industrial practice. It is necessary, therefore, to reduce these processes to practice in order to produce the wide variety of value-added consumer and industrial products. The approach of this proposal is to develop more efficient industrial processes for converting vegetable oils to improved consumer and industrial products. The vegetable oils used in novel syntheses will be derived from Canadian crops with unique chemistry and/or low cost including canola, flax, high-oleic canola, solin flax, coriander, camelina and rapeseed.  Modified oils will be tested for relevant chemical and physical properties but it is not the intention of this research to formulate new products. Formulation of new products will be conducted by an array of Canadian companies and university collaborators who are currently studying and developing new products. When efficient syntheses and concentration methods are developed quantities of products sufficient for evaluation by collaborators will be prepared. This in kind or cash contribution will be supplied separately through collaboration.  Processes will be developed to inexpensively convert vegetable oils to products that: 1) remain liquid at low temperature (-40C); 2) have low viscosity (<4 cP); 3) have high viscosity (>200 cP); have high polarity; 4)have low polarity; 5) have enhanced oxidative stability (>10 h AOM).  Patented methods and trade secrets have been developed by the applicant to prepare alkyl esters and conjugate fatty acids for industrial applications. The project will result in the training of a Ph.D. and M.Sc. candidates and summer students. While exploring Diels-Alder chemistry and the modification of lipid properties the students will be mentored by a supervisor with significant experience in industrial process design and intellectual property protection.