Evolution of hypervariable flax orbitides

高变亚麻轨道的演化

• 批准号: RGPIN-2015-05516
• 负责人: Reaney, Martin
• 金额: $ 2.46万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=590479
• 关键词: Evolution; hypervariable; flax; orbitides

Natural products are the basis for most medicines and biologically active substances. It was thought that enzymes produced most natural products but it was recently discovered that ribosomes also produce natural product precursors. Plants, mammals, bacteria and fungi all produce N to C cyclized peptide natural products. The accumulation of cyclic peptides can be significant and the number of possible new natural products is staggering. There are more potential peptides than known compounds. Cyclic peptides called orbitides have been discovered in a range of food and medicinal plants.

天然产物是大多数药物和生物活性物质的基础。人们认为酶产生大多数天然产物，但最近发现核糖体也产生天然产物前体。植物、哺乳动物、细菌和真菌都产生N到C环化肽天然产物。 环肽的积累可能是显着的，可能的新天然产物的数量是惊人的。有更多的潜在肽比已知的化合物。在一系列食品和药用植物中发现了称为orbitides的环肽。