Thin metal film sputtering system

金属薄膜溅射系统

• 批准号: 359631-2008
• 负责人: Masson, JeanFrançois
• 金额: $ 5.79万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=365631
• 关键词: Thin; metal; film; sputtering; system

The research program to be supported by this RTI focuses on the development of scanning probe Surface Plasmon Resonance (SPR) microscopy and the improvement of conventional SPR sensors for the quantification of cancer proteins. The sensing technology will be applied for the highly sensitive and spatially-resolved quantification of proteins released by cells and measurement of cellular morphology. To perform scanning probe SPR microscopy, we will develop micro-plasmonic structures on the tip apex of AFM cantilevers. Hence, we will optimise the response of SPR microbiosensors by tuning various experimental parameters: cantilever material and geometry, thin metal film (Au or Ag) and its thickness, and data analysis methods. Our developments will be applied to a model system involving the measurement of chemokines messenger proteins. Chemokines have been recently identified as major contributors to the signalling mechanism regulating cancer growth and metastasis. Specifically, the chemokine CXCL12, involved in breast cancer metastasis will be investigated. Thus, developing scanning probe SPR microscopy for chemokine sensing will result in a tool to investigate the role of chemokines at the cellular level.We request the acquisition of a thin metal film sputter coater to accomplish our research program. This instrument will be used to deposit metallic thin films of thickness varying from 1 to 60 nm. This instrument is necessary to manufacture SPR sensors for scanning probe SPR microscopy and for conventional SPR sensors. Titanium, gold or silver films will be deposited onto the apex of AFM cantilevers for scanning probe SPR microscopy or onto glass substrates for conventional SPR biosensors. Daily use of the thin metal film sputter coater is anticipated. The acquisition of a thin metal film sputter coater is necessary to the success of our research program.

该RTI支持的研究计划侧重于开发扫描探针表面等离子体共振（SPR）显微镜和改进传统SPR传感器，用于癌症蛋白质的定量。该传感技术将用于细胞释放的蛋白质的高灵敏度和空间分辨定量以及细胞形态的测量。为了进行扫描探针SPR显微术，我们将在AFM杠杆的尖端上开发微等离子体结构。因此，我们将通过调整各种实验参数来优化SPR微生物传感器的响应：悬臂梁材料和几何形状，薄金属膜（Au或Ag）及其厚度，以及数据分析方法。我们的发展将被应用到一个模型系统，涉及测量趋化因子信使蛋白。趋化因子最近已被确定为调节癌症生长和转移的信号传导机制的主要贡献者。具体而言，将研究参与乳腺癌转移的趋化因子CXCL12。因此，开发扫描探针SPR显微镜的趋化因子传感将导致一种工具，以调查在细胞水平上的趋化因子的作用。我们要求收购一个薄的金属膜溅射镀膜机来完成我们的研究计划。该仪器将用于存款金属薄膜的厚度变化从1到60纳米。该仪器是制造用于扫描探针SPR显微镜和常规SPR传感器的SPR传感器所必需的。钛、金或银膜将沉积在AFM杠杆的顶点上用于扫描探针SPR显微镜或沉积在玻璃基底上用于常规SPR生物传感器。预计金属薄膜溅射镀膜机的日常使用。金属薄膜溅射镀膜机的收购是必要的，我们的研究计划的成功。