Regulation of Megakaryocyte and Platelet Survival in Malignancy

恶性肿瘤中巨核细胞和血小板存活的调节

• 批准号: nhmrc : GNT1079250
• 负责人: Dr Ashley Ng
• 金额: $ 52.01万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-megakaryocyte-platelet-survival-malignancy/1345270
• 关键词: Regulation; Megakaryocyte; Platelet; Survival; Malignancy

In this grant we will investigate how blood cells called platelets are produced in normal conditions and during disease. Platelets are blood cells that stop us from bleeding when we get a cut. When too many platelets accumulate, there is an increased risk of blood clots forming. This project grant will help us learn how platelet numbers swell in response to some blood and ovarian cancers, and the mechanisms that control cell death in platelets and the cells that produce them.

在这项拨款中，我们将研究在正常情况下和在疾病期间，称为血小板的血细胞是如何产生的。当我们被割伤时，血小板是阻止我们流血的血细胞。当血小板积聚过多时，血栓形成的风险就会增加。这一项目拨款将帮助我们了解一些血液和卵巢癌如何导致血小板数量膨胀，以及控制血小板和产生它们的细胞死亡的机制。