Regulation of Megakaryocyte and Platelet Survival in Malignancy

恶性肿瘤中巨核细胞和血小板存活的调节

• 批准号: nhmrc : 1079250
• 负责人: Dr Ashley Ng
• 金额: $ 35.8万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-megakaryocyte-platelet-survival-malignancy/518648
• 关键词: Regulation; Megakaryocyte; Platelet; Survival; Malignancy

In this grant we will investigate how blood cells called platelets are produced in normal conditions and during disease. Platelets are blood cells that stop us from bleeding when we get a cut. When too many platelets accumulate, there is an increased risk of blood clots forming. This project grant will help us learn how platelet numbers swell in response to some blood and ovarian cancers, and the mechanisms that control cell death in platelets and the cells that produce them.

在这笔拨款中，我们将研究在正常条件下和疾病期间如何产生称为血小板的血细胞。血小板是一种血细胞，可以在我们受伤时阻止流血。当过多的血小板积聚时，形成血栓的风险就会增加。该项目拨款将帮助我们了解血小板数量如何因某些血液癌和卵巢癌而增加，以及控制血小板和产生血小板的细胞死亡的机制。