Role of Erg in B-cell Acute Lymphoblastic Leukaemia

Erg 在 B 细胞急性淋巴细胞白血病中的作用

• 批准号: nhmrc : 1122783
• 负责人: Dr Ashley Ng
• 金额: $ 51.13万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-erg-b-lymphoblastic-leukaemia/947017
• 关键词: Role; Erg; cell; Acute; Lymphoblastic

Acute lymphoblastic leukaemia (ALL) is a lethal blood cancer for which current treatments are suboptimal. Over-expression of the ERG gene has been associated with the poor prognosis B cell ALL called Ph+ B-ALL. We have recently shown that loss of Erg prevents disease development in disease models. We hypothesise that expression of ERG is a key driver of Ph+ B-ALL and propose to define this role and identify new opportunities for development of specific novel therapeutics.

急性淋巴细胞白血病（ALL）是一种致命的血液癌症，目前的治疗方法效果不佳。 ERG 基因的过度表达与预后不良的 B 细胞 ALL（称为 Ph+ B-ALL）有关。我们最近表明，在疾病模型中，Erg 的丧失可以预防疾病的发展。我们假设 ERG 的表达是 Ph+ B-ALL 的关键驱动因素，并建议定义这一作用并确定开发特定新型疗法的新机会。