Genetic and molecular characterisation of Erg function in normal and malignant haemopoiesis

点击翻译按钮获取中文摘要

In the human body, production of blood cells to carry oxygen, stop bleeding and fight infection is highly controlled. The transcription factor Erg is critical in delivering proper instructions so blood cells develop normally. Too much or too little Erg leads to abnormal blood cell development and blood diseases such as seen in children with Down Syndrome or patients who develop acute leukemia. The reasons why this happens will be investigated to allow for better treatment of these conditions.