Genetic and molecular characterisation of Erg function in normal and malignant haemopoiesis

正常和恶性造血过程中 Erg 功能的遗传和分子特征

• 批准号: nhmrc : 1060179
• 负责人: Dr Ashley Ng
• 金额: $ 43.18万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genetic-molecular-characterisation-malignant-haemopoiesis/454803
• 关键词: Genetic; molecular; characterisation; Erg; function

In the human body, production of blood cells to carry oxygen, stop bleeding and fight infection is highly controlled. The transcription factor Erg is critical in delivering proper instructions so blood cells develop normally. Too much or too little Erg leads to abnormal blood cell development and blood diseases such as seen in children with Down Syndrome or patients who develop acute leukemia. The reasons why this happens will be investigated to allow for better treatment of these conditions.

在人体中，运送氧气、止血和对抗感染的血细胞的产生受到高度控制。转录因子Erg在传递正确的指令以使血细胞正常发育方面至关重要。过多或过少的Erg会导致异常的血细胞发育和血液疾病，如唐氏综合症儿童或急性白血病患者。将调查发生这种情况的原因，以便更好地治疗这些疾病。