Self assembling and targeting smart biomaterials for Dengue virus diagnostics and therapeutics

用于登革热病毒诊断和治疗的自组装和靶向智能生物材料

• 批准号: 336491-2006
• 负责人: Suresh, Mavanur
• 金额: $ 7.25万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Strategic Projects - Group
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=365904
• 关键词: Self; assembling; targeting; smart; biomaterials

This grant relates to the detection, prevention and treatment of Dengue virus infection. The virus is a mosquito borne virus that infects 100 million individuals worldwide. In its severe form it can cause death in 5% of the individuals. Two strains of this virus is now also prevalent in North America. The objectives of this research in collaboration with a Canadian company (Cangene Inc, Winnipeg and Toronto) is to develop smart biomaterials for detection and treatment of the disease. More specifically, a simple swab or dipstick based immunoassay will be developed for non-invasive detection of infected individuals. Similar antibodies are also to be tested for prevention and treatment of infection in tissue culture and mouse models of dengue viral infection.

这笔赠款涉及登革热病毒感染的检测、预防和治疗。该病毒是一种由蚊子传播的病毒，感染全球 1 亿人。严重时可导致 5% 的人死亡。这种病毒的两种毒株现在也在北美流行。这项研究与加拿大公司（Cangene Inc，温尼伯和多伦多）合作的目标是开发用于检测和治疗该疾病的智能生物材料。更具体地说，将开发一种简单的基于拭子或试纸的免疫测定法，用于对感染个体进行非侵入性检测。类似的抗体也将在登革热病毒感染的组织培养和小鼠模型中用于预防和治疗感染进行测试。