Regulation of TNF expression in inflammation and cancer

炎症和癌症中 TNF 表达的调节

• 批准号: nhmrc : 1127885
• 负责人: Dr Philippe Bouillet
• 金额: $ 49.68万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-tnf-expression-inflammation-cancer/948085
• 关键词: Regulation; TNF; expression; inflammation; cancer

By studying a spontaneous mutation in mice, we have found an error in the TNF gene (a major factor in many inflammatory diseases) that causes severe arthritis, heart valve disease and gut inflammation. We have also identified new regulators of TNF expression, which might be useful therapeutic targets to limit inflammation. We intend to study the role of these regulators in controlling the expression of TNF, and the link between chronic inflammation and the development of cancer.

通过研究小鼠的自发突变，我们发现了TNF基因（许多炎症性疾病的主要因素）的错误，导致严重的关节炎，心脏瓣膜疾病和肠道炎症。我们还鉴定了TNF表达的新调节因子，这可能是限制炎症的有用治疗靶点。我们打算研究这些调节因子在控制TNF表达中的作用，以及慢性炎症和癌症发展之间的联系。