Apoptosis and Stem Cells in Cancer Development and Therapy

癌症发展和治疗中的细胞凋亡和干细胞

• 批准号: nhmrc : 1016701
• 负责人: Dr Philippe Bouillet
• 金额: $ 1523.78万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Program Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/apoptosis-stem-cells-development-therapy/109803
• 关键词: Apoptosis; Stem; Cells; Cancer; Development

To improve cancer therapy, we are studying two cancer hallmarks: enhanced cell survival and stem cell-like behaviour. As we discovered, cell death is often blocked in cancer cells. Hence, we are attempting to develop drugs that flip the natural ‘cell death switch’. Stem cells are rare cells that generate entire tissues, as we showed for the breast. Certain cancers may be driven by ‘rogue’ stem cells. If so, eradication of these rare cells within the bulk tumour may require novel therapies.

为了改善癌症治疗，我们正在研究两个癌症标志：增强细胞存活和干细胞样行为。正如我们所发现的，细胞死亡通常在癌细胞中被阻止。因此，我们正在尝试开发能够翻转自然“细胞死亡开关”的药物。干细胞是一种罕见的细胞，可以生成整个组织，就像我们在乳腺中展示的那样。某些癌症可能由“流氓”干细胞驱动。如果是这样的话，根除大块肿瘤中的这些罕见细胞可能需要新的治疗方法。