Generation of mouse models to study the roles of different Bcl-2 family members in the regulation of apaptosis

建立小鼠模型来研究不同 Bcl-2 家族成员在细胞凋亡调节中的作用

• 批准号: nhmrc : 516776
• 负责人: Dr Philippe Bouillet
• 金额: $ 28.06万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/generation-mouse-models-regulation-apaptosis/115684
• 关键词: Generation; mouse; models; study; roles

Programmed cell death, or apoptosis, is required for the removal of infected, damaged or unwanted cells and its disrupted regulation is implicated in cancer, autoimmunity and degenerative disorders. The Bcl-2 family of proteins are key regulators of apoptosis. We propose to generate several mouse models to better understand the relationships between the different members of the Bcl-2 family in an effort to control this pathway for therapeutic purposes.

程序性细胞死亡，或称细胞凋亡，是清除感染、受损或不需要的细胞所必需的，其调节中断与癌症、自身免疫和退行性疾病有关。Bcl2蛋白家族是细胞凋亡的关键调节因子。我们建议建立几个小鼠模型，以更好地了解Bcl-2家族不同成员之间的关系，以努力控制这一途径用于治疗目的。