DOES BCL-G, A BH3-ONLY PROTEIN, PLAY A ROLE IN INFLAMMATION-ASSOCIATED COLON CANCER?

BCL-G（一种仅包含 BH3 的蛋白质）在炎症相关结肠癌中发挥作用吗？

• 批准号: nhmrc : 1051506
• 负责人: Dr Philippe Bouillet
• 金额: $ 27.91万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-bcl-g-colon-cancer/112222
• 关键词: DOES; BCL; BH3; ONLY; PROTEIN

Deregulation of the function of several members of the Bcl-2 family has been shown to be an aggravating factor in autoimmune diseases and cancer. Bcl-G is a new and poorly characterized member of this family. We have produced essential tools to study the physiological function of Bcl-G, and discovered that it plays a role in inflammatory bowel disease. We now plan to investigate its possible role in inflammation-associated colon cancer.?

Bcl-2家族的几个成员的功能失调已被证明是自身免疫性疾病和癌症的加重因素。Bcl-G是该家族的一个新成员，其特征不明显。我们已经开发出研究Bcl-G生理功能的必要工具，并发现它在炎症性肠病中发挥作用。我们现在计划研究它在炎症相关结肠癌中的可能作用。