Reprogramming human fibroblasts into induced trophoblast stem cells

将人成纤维细胞重编程为诱导滋养层干细胞

• 批准号: nhmrc : 2004774
• 金额: $ 88.91万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/reprogramming-human-fibroblasts-stem-cells/1780410
• 关键词: Reprogramming; human; fibroblasts; into; induced

We have been able to generate artificial human trophectoderm which is the tissue that creates the placenta. This will allow us to do research in how the genes control the fate of these cells without the need of human embryos or placenta. We anticipate that the derivation and characterising these cells will revolutionise placenta research, which in turn will contribute to the establishment of new therapies for placenta disease and infertility.

我们已经能够制造人造的人类滋养外胚层，它是制造胎盘的组织。这将使我们能够研究基因如何控制这些细胞的命运，而不需要人类胚胎或胎盘。我们预计，这些细胞的衍生和表征将彻底改变胎盘研究，这反过来将有助于建立胎盘疾病和不孕症的新疗法。