Revealing how the mammalian preimplantation embryo undergoes compaction

揭示哺乳动物植入前胚胎如何经历压缩

• 批准号: nhmrc : 1062263
• 负责人: Dr Nicolas Plachta
• 金额: $ 47.02万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/revealing-mammalian-preimplantation-undergoes-compaction/454973
• 关键词: Revealing; how; mammalian; preimplantation; embryo

The first morphological process critical for mammalian development is embryo compaction. During compaction, cells change their morphology from rounded to wedge-like. The mechanisms controlling embryo compaction remain unclear. We recently discovered that during compaction, cells extend long membrane protrusions on top of each other. In this Project we will establish the role of these protrusion in controlling embryo compaction and reveal the mechanisms underlying their formation.

哺乳动物发育的第一个关键形态学过程是胚胎致密化。在压实过程中，细胞改变其形态从圆形到楔形。控制胚胎致密化的机制尚不清楚。我们最近发现，在压实过程中，细胞在彼此的顶部延伸长的膜突起。在这个项目中，我们将建立这些突起在控制胚胎压实中的作用，并揭示其形成的机制。