REVEALING MOLECULAR MECHANISMS OF THE SYNCHROTRON RADIATION-INDUCED BYSTANDER EFFECT

揭示同步辐射引起的旁观者效应的分子机制

• 批准号: nhmrc : 1027558
• 负责人: A/Pr Olga Martin
• 金额: $ 28.63万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/revealing-molecular-mechanisms-bystander-effect/110581
• 关键词: REVEALING; MOLECULAR; MECHANISMS; SYNCHROTRON; RADIATION

Radiotherapy, a major treatment for more than half of cancer patients, is based on the dogma that radiation kills targeted cells. The radiation-induced bystander effect, by which the neighbours of irradiated cells can also damaged, is a new paradigm. What is the "danger signal" which induces DNA damage in un-irradiated normal tissues, and what minimal volume of tissue needs to be irradiated to induce bystander damage? The answers could have a major impact on optimising radiotherapy treatment.

放射治疗是超过一半的癌症患者的主要治疗方法，它是基于辐射杀死靶细胞的教条。辐射诱导的旁观者效应是一种新的范式，通过这种效应，受辐射细胞的邻居也会受到损害。在未受照射的正常组织中，导致DNA损伤的“危险信号”是什么？需要照射多少组织才能引起旁观者的损伤？这些答案可能会对优化放射治疗产生重大影响。