Reversing the biomechanical dysregulation of cancer cell signalling to improve targeted therapies

逆转癌细胞信号传导的生物力学失调以改善靶向治疗

• 批准号: nhmrc : 1129766
• 金额: $ 45.28万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/reversing-biomechanical-dysregulation-targeted-therapies/948460
• 关键词: Reversing; biomechanical; dysregulation; cancer; cell

The limited success of cancer drugs is dependent on many factors including the physical properties (stiffness) of a tumour. In particular whether a tumour is soft or stiff affects how it responds to treatment. Combining classical biology with engineering to generate 3D models that mimic tumours, along with cutting-edge imaging technology, we will determine how we can target the physical properties of tumours together with already approved cancer drugs to improve treatment and patient outcome.

癌症药物的有限成功取决于许多因素，包括肿瘤的物理性质（硬度）。特别是肿瘤是软的还是硬的会影响它对治疗的反应。结合经典生物学与工程学，生成模拟肿瘤的3D模型，沿着尖端成像技术，我们将确定如何将肿瘤的物理特性与已经批准的癌症药物结合起来，以改善治疗和患者预后。