Role of BIME1 in breast cancer

我们已经在5%的乳腺癌中发现了一种名为BIME1的新型DNA元件的遗传异常。该提案旨在确定这些遗传异常是否有助于乳腺肿瘤的发生，以及哪些基因和途径受到这些突变的影响。该提案的结果可能会导致乳腺癌新疗法的开发，或可能影响对这些遗传异常患者的现有疗法的选择。

We have identified genetic abnormalities in 5% of breast cancers that fall in a novel DNA element called BIME1. This proposal aims to determine whether these genetic abnormalities contribute to breast tumourigenesis and which genes and pathways are affected by these mutations. The outcomes of this proposal may lead to the development of novel therapies for breast cancer or could influence the choice of existing therapies for patients that harbour these genetic abnormalities.